Endocrine Abstracts

Background and aims: To investigate the level of lipoprotein associated phospholipase A2 (LpPLA2), nitrogen oxide (NO) in patients with type 2 diabetes (DM2) and nonalcoholic fatty liver disease (NAFLD) against a variety of hypoglycemic therapies (HT).Materials and methods: A one-stage examination of 90 patients with DM 2 and NAFLD was carried out. Men ratio 37.8%, women ratio 62.2%, mean age 57.3±11.6 years. Mean HbAlc 7.4±1.82%. According to ...

Introduction: The formation of oxidative stress in the biological reaction of inflammation is accompanied by the formation of methylglyoxal (MG), which initiates the glycosylation reaction of proteins. When hyperglycemia MG content significantly increased. MG interacts with the amino groups of lysine and arginine to form further glycation end products (CNG). Glycation is due to the ability of glucose to form irreversible chemical compounds of CNG with amino groups of proteins....

Introduction: Retinol binding protein (RSP) is a member of the adipokine family associated with insulin resistance (IR). With an excess of free fatty acids, the binding of insulin by hepatocyte receptors decreases and hyperinsulinemia develops. RSP is a transport protein for retinol, synthesized in hepatocytes and adipocytes. The level of RSP increased in patients with obesity, diabetes mellitus and non-alcoholic fatty liver disease (NAFLD) correlated positively with the sever...

Pathogenesis of Non-alcoholic fatty liver disease in 90% combined with diabetes mellitus (DM) of the second type. Factors cutting: abdominal obesity, excessive content of free fatty acids. Development of insulin resistance through protein kinase. Violation of the transmission of insulin signal leads to damage to the endothelium. Glycation of nitric oxide synthase leads to the development of diabetic complications and violates the sensitivity of the insulin receptors.<p cla...

Purpose of the study: Assess the criteria for early diagnosis of the risk of developing diabetic foot syndrome as a microvasculature using laser Doppler flowmetry and tissue metabolism using fluorescence spectroscopy in diabetic patients.Materials and methods: The studies are carried out with the help of the Laser Diagnostic LASMA ST Apparatus ‘(OOO NPP’ LAZMA’, Moscow) on the plantar surface of the big toe in three stages: resting state -...